Gender-based violence (GBV) remains a significant concern across the Indo-Pacific region, yet practitioner insights into engaging men and boys in prevention and intervention remain underexplored. This paper draws on a hybrid roundtable held in 2025, involving 32 practitioners, policymakers, and researchers from across the Indo-Pacific, to examine frontline experiences of responding to GBV. Using reflexive thematic analysis, six themes were identified: identity and context, principles for engagement, structural drivers of violence, approaches to engaging men and boys, resourcing, and children. Findings highlight that cultural and community context fundamentally shapes how men and boys can be engaged, that whole-of-community and intersectional approaches are often favoured over siloed perpetrator programs across the region, and that declining resources and growing anti-feminist backlash present significant challenges to the sector. Practitioners emphasised the importance of survivor-centred, accountable, and ethical engagement with men and boys, while underscoring the need for innovative practice. This paper contributes practitioner-centred insights for policy and practice development in working with men and boys to end GBV across the Indo-Pacific.