The human gut-brain axis is a two-way communication network linking the digestive system with the brain, playing a crucial role in regulating mood, cognition, and overall mental health. This connection is largely mediated by the gut microbiome, a vast community of microbes that produce neurotransmitters, regulate immune responses, and influence the production of hormones critical for brain function.

When the gastrointestinal environment becomes imbalanced—due to poor diet, stress, antibiotics, or illness—the gut microbiome can become disrupted, leading to increased inflammation and a "leaky gut," where toxins and microbes pass into the bloodstream. This imbalance can negatively impact the brain, potentially leading to cognitive decline, mood disorders, and impaired memory, as inflammatory signals travel to the brain, disrupting its function and altering neurotransmitter levels. Maintaining a balanced gut environment is therefore essential for optimal brain health and emotional well-being.

Research conducted at the QUT showed specific combinations of probiotics improved depressive scores in traditional non-responsive patients, citing the first probiotic formulation to effectively control and reduce depressive events.

As mental health prevalence data accelerates, new therapeutic options must be realised and made available to the greater public.

The presenter will focus their presentation around this research and its outcomes whilst offering insightful information of the role the gut plays in human cognitive and emotional response.

Three Key Learnings:
1. understand new probiotics to support depressive patients
2. understanding of the gut/brain axis
3. understanding of prevalence data and the pressing need for new strategies