Neurodivergent individuals are disproportionately affected by a range of chronic medical conditions, including but not limited to chronic pain syndromes, gastrointestinal disorders, and epilepsy. These co-occurring conditions not only reflect complex neurological and biological underpinnings but also intersect significantly with mental health outcomes. This presentation will explore the emerging research on the biological mechanisms that may contribute to these comorbidities, as well as the lived experiences of neurodivergent individuals managing both physical and psychological challenges. Emphasizing the interplay between body and brain, we argue for a holistic, integrative model of care—one that moves beyond narrow diagnostic categories to address the full spectrum of neurodivergent health.