Introduction: Major Depressive Disorder (MDD) is a global threat yet adolescents could vary from adults in symptom presentation. Being vulnerable for interpersonal stresses, its role in the symptom structure of depression remains unclear. While being important in understanding age and cultural manifestation of depression, the current paper adopts the network approach and makes use of a comprehensive checklist of depressive symptoms of the Multidimensional Depression Assessment Scale (MDAS). The study entangled the role of interpersonal symptoms in the cluster of emotional, cognitive, and somatic symptoms and the variations across ethnic groups of Asian and Caucasian adolescents. Method: A sample of 6348 adolescents between the age of 12-18 was recruited through Qualtrics in Hong Kong, Taiwan, UK and the Netherlands. Divided based on their ethnicity of Asian and Caucasian, the network model of symptoms in MDAS was established using Ising modelling to examine the interconnection between symptoms. The central symptom node was examined and the network structure was compared across the two ethnic groups. Results: The result showed that interpersonal symptoms of feeling a burden on others, feeling less attractive than others, together with low energy and low mood are central traits. A significant difference in depressive symptom connection was found between Asian and Caucasian adolescents, suggesting a greater tendency of interpersonal manifestation in Caucasian sample that may contribute to unrecognized depression and undertreatment. Limitations: A diversified community sample was recruited and a larger sample could be included in the future for large number of nodes.